Randomized controlled study of desloratadine citrate and loratadine in the treatment of allergic rhinitis
نویسندگان
چکیده
Objective: To observe the clinical efficacy and safety of desloratadine citrate disodium in the treatment of allergic rhinitis (AR). Methods: 200 patients with AR treated at otorhinolaryngology department of Sichuan Provincial People’s Hospital from January, 2012 to October, 2014 were selected for this study. They were randomly divided into therapeutic group and control group with 100 patients in each. And there was no obvious difference in general data between two groups. The therapeutic group was treated with desloratadine citrate disodium tablets with daily dosage of 8.8 mg by oral administration, while the control group was given loratadine with daily dosage of 10 mg by oral administration. The treatment course was one month. All the patients were not given corticosteroids and other antihistamines. Observe symptoms before and after the treatment, signs score and clinical efficacy in two groups. We intraperitoneal injected 100 μg of ovalbumin 2 times to build sensitized model in ICU mic and separated splenic lymphocyte; pretreated with 1.5 mol/L esloratadine citrate disodium and loratadine, and then added 200 mg/L ovalbumin for stimulation; the influence of esloratadine citrate disodium and loratadine on lymphocyte releasing prostaglandin E2, leukotrienes, interleukin-4, interleukin-5 and tumor necrosis factor were detected and compared by ELISA method. Results: In the 99 cases selected in therapeutic group, 58 cases were markedly effective, 34 cases were effective, 7 cases were ineffective, and the total effective rate was 92.9%. In the 98 cases selected in control group, 7 cases were markedly effective, 48 cases were effective, 23 cases were ineffective, and the total effective rate was 76.5%. There was statistically significant difference in the total effective rate between the two groups (P<0.05). In mouse sensitization model, compared with those in the loratadine group, desloratadine citrate disodium could significantly decrease the levels of lymphocytes releasing PGE2, LTB4, IL-4, IL-5, TNF-α. Conclusion: Compared with loratadine, the clinical efficacy of desloratadine citrate disodium tablets is better in the treatment of AR and with good safety.
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